Global metabolic profiling of human osteoarthritic synovium
نویسندگان
چکیده
منابع مشابه
Global metabolic profiling of human osteoarthritic synovium.
Osteoarthritis (OA) is a debilitating disease associated with pain and loss of function in numerous diarthrodial joints of the body. Assessments of the severity and/or progression of OA are commonly based on radiographic stages and pain level, which aren't always correlated to severity of disease or joint dysfunction and may be confounded by other factors(1). There has been recent interest in i...
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Osteoarthritis (OA) is a degenerative joint disease affecting cartilage and is the most common form of arthritis worldwide. One third of OA patients have severe synovitis and less than 10% have no evidence of synovitis. Moreover, synovitis is predictive for more severe disease progression. This offers a target for therapy but more research on the pathophysiological processes in the synovial tis...
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BACKGROUND Glucosamine (GlcN) used by patients with osteoarthritis was demonstrated to reduce pain, but the working mechanism is still not clear. Viscosupplementation with hyaluronic acid (HA) is also described to reduce pain in osteoarthritis. The synthesis of HA requires GlcN as one of its main building blocks. We therefore hypothesized that addition of GlcN might increase HA production by sy...
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Methods Healthy men and women ages 19-30 who self-reported 150-450 minutes of aerobic exercise per week were recruited at two different laboratories (n= 48; n= 40). All participants were provided with the same three meals and beverages to consume in the 24 hours before each exercise session. Participants consumed one test beverage, while exercising, during each visit including water, a caloric ...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2012
ISSN: 1063-4584
DOI: 10.1016/j.joca.2011.10.010